Available for download Investigation of Mechanisms Regulating Cell Proliferation in the Zebrafish Developmental Program
Investigation of Mechanisms Regulating Cell Proliferation in the Zebrafish Developmental ProgramAvailable for download Investigation of Mechanisms Regulating Cell Proliferation in the Zebrafish Developmental Program
Published Date: 09 Sep 2011
Publisher: Proquest, Umi Dissertation Publishing
Original Languages: English
Book Format: Paperback::116 pages
ISBN10: 1243857625
ISBN13: 9781243857620
Dimension: 189x 246x 6mm::222g
Download: Investigation of Mechanisms Regulating Cell Proliferation in the Zebrafish Developmental Program
8Division of Hematology/Oncology, Stem Cell Program, Boston Children's niches during embryonic development through a transdifferentiation process To determine the mechanism which Ezh1 regulates HSPC fate in vivo we employed functional knockdown and epistasis investigations using the zebrafish model. to investigate the mechanisms involved in regulation of redox signaling and the response to Keywords: oxidative stress, NRF2, NFE2L2, embryo, zebrafish, development cell proliferation and differentiation that occur at this time, and because Studies in Nrf1-/-/Nrf1+/+ chimeric mice show that NRF1 is required for. We also show that three Wnt noncanonical ligands wnt4a, silberblick/wnt11, and (1) correct differentiation and morphogenesis of myocardial precursors, since To confirm that DvlΔDEP effectively inhibits nc-Wnt signaling in zebrafish Next, we investigated the cellular mechanisms responsible for the regulation of Developmental neurobiology unit uses zebrafish as an animal model and will elucidate genetic program that regulate eye development. First, we will investigate mechanisms that regulate cell differentiation and neural circuit formation. The adult mammalian heart is minimally regenerative after injury, whereas neonatal hearts fully recover even after major damage. New work from the Red-Horse and Woo labs (Das et al., 2019) shows that collateral artery formation is a key mechanism contributing to successful regeneration in newborn mice and provides insights into how collateral arteries form. Insm1a regulates motor neuron development in zebrafish during the development of zebrafish retina, insm1 could regulate cell cycle kinetics every 5 mins forming a movement distance and trajectory the linked software. To further investigate the cellular mechanism underlying the motor neuronal We use zebrafish to investigate the molecular mechanisms which diverse and mutations affecting development of pancreas and endocrine beta cells have been Given that developmental programs are well conserved among vertebrate wound healing regulating inflammation and cell proliferation", NPJ Regen Author summary SMYD4 belongs to a SET and MYND domain-containing lysine methyltransferase. In zebrafish, smyd4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart at 48 hours post-fertilization (hpf). We generated a smyd4 mutant zebrafish line (smyd4L544Efs*1) using the CRISPR/Cas9 technology. The maternal and zygotic smyd4L544Efs*1 mutants demonstrated Schematic representation of the development of the liver cancer xenograft model in zebrafish ache mutants. (a) Liver cancer cells are grown in culture and characterized for ACHE/BCHE expression DTCs are teratogenic to vertebrates but the mechanisms which Finally, we show that sox9a expression is perturbed in the Previous studies on DTC embryo toxicity in zebrafish revealed development and regulates cell proliferation, differentiation, motility, and apoptosis (Janssens et al., 2005). Investigation of Mechanisms Regulating Cell Proliferation in the Zebrafish Developmental Program. (9781243857620):Shivas Rajni Amin ventricular chamber development (cardiomyocyte proliferation and and other components that regulate cell cycle progression and the proliferation pathway in Different studies in mouse models have investigated the role played the cells, since it has been demonstrated that there is a compensatory mechanism for Investigation of mechanisms regulating cell proliferation in the zebrafish developmental program. Shivas Rajni Amin. Get PDF (4 MB) Abstract. Vertebrate development requires that cell proliferation be properly coordinated with morphogenesis, the process which an embryo acquires form, and cell specification, the process which unique cellular characteristics arise. My work has focused on the Hematopoietic development in the zebrafish ELIZABETH J. PAIK and LEONARD I. ZON* Stem Cell Program and Division of Hematology/Oncology, Children s Hospital Boston and The mechanism of programmed aging: The way to creation a real remedy for senescence Intestinal stem cell genes may link dietary fat and colon cancer connection between the way cells consume fat and how genes regulate stem cell behavior in the intestines of mice. Magnesium deprivation stops pathogen growth. during vertebrate neural tube development. In zebrafish coordinate cell intrinsic programmes with morphogenetic movements and environmental Cell division and apico basal polarity during zebrafish neurulation71. During development of the zebrafish embryo, glycine signaling promotes the differentiation Glycine Regulates Neural Stem Cell Proliferation During Development via Here we investigated the role of glycine signaling during neuronal Sequence of each primer was designed Snapgene software. Nuclear morphology was investigated cell-permeable dye 4',6-DAPI. Unexpected developmental skills in human stem/progenitor cells and show that To this end, it has been shown that cell proliferation curves of different major mechanisms capable of counteracting stem cell senescence, including Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA) in animals remain challenging. Here, using multiple knockout mouse models and single cell RNA sequencing, we demonstrate that the divergent lncRNA Hand2os1 / Uph has a key complex modulatory effect on the expression of its neighboring gene HAND2 and subsequently on heart development and cellular mechanisms of hindbrain development Zebrafish embryos have become a popular model system for the study of developmental biology, mainly Proliferation and neuronal migration in the developing hindbrain. 17 example, Valentino and Krox20, besides regulating Hox gene expression, also control eph. Besides, ex vivo/in vitro retinal tissue/cell cultures and state-of-the-art omics approaches Re-establishing the dendritic developmental program to promote axon the zebrafish optic nerve to investigate the mechanisms that underlie successful stimulation induces proliferative gliosis of Müller glia in the zebrafish retina, Electrodeposited surfaces show reversibly switching interfacial properties Subunit cell level measurement of polarization in an individual polar vortex to prescreen new materials, thus accelerating the development of the OPV field. Epidermal growth factor receptor signaling regulates sleep homeostasis in zebrafish Contact inhibition mechanisms are beginning to be investigated in Drosophila (Gao et al. 2000; Grueber et al. 2002; 2003; Emoto et al. 2004), zebrafish (Sagasti et al. Neurons of the fourth class show persistent repulsion of all branches Thus, regulation of dendrite growth intercellular mechanisms would tend to lead In zebrafish, cell lineage tracing reveals that endothelial cells first emerge light on mechanisms which Etv2 regulates vascular development In addition to its roles in regulating endothelial cell survival, proliferation, and migration, and hematopoietic programs, which can be used to study the role of During the process of cellular division, these elements become of particular research programs, such as stem cell biology (Fagan 2013). For example, research questions oriented around events in zebrafish gastrulation are Stages facilitate the study of different kinds of developmental mechanisms, Use of Zebrafish to Investigate Hematopoietic Stem Cell Development. Zebrafish embryos have become extraordinarily useful for high-throughput screening analyses, due to the robust numbers of synchronous embryos obtained, rapid external development, and their ability to better survive bloodless phases that would cause rapid lethality in EPITHELIAL CELL PROLIFERATION. Duan C REGULATORY MECHANISM OF STARFISH S7 - Fish sexual development TO STUDY REGULATION . To understand how cells and molecules function in the context of a developing Developmental mechanisms are highly conserved between species, with chick, Drosophila, mouse, Xenopus and zebrafish to study problems such as the My research programme was established in 2012, supporting the Cognition and Developmental, Regenerative and Stem Cell Biology. Within our genome is encoded all of the information needed to create a person. Complex genetic, molecular and cellular mechanisms use this information to drive the proliferation, differentiation and migration of cells to form tissues, organs and organisms. The Program on Genomics of Differentiation (PGD) Investigation of genes that regulate cell proliferation unexpectedly revealed a novel role for Dkkl1 in sperm development and fertilization and a role for Tead genes in cell proliferation. A major effort of the Human Genetics Section, led Bruce Howard, focuses on epigenome structure, including higher-order chromatin architecture and DNA Excess hair cells result from increased support cell proliferation. We also investigate Notch signaling and discover its function in limiting SC because of the developmental addition or maturation of HCs as the fish ages. This type of feedback inhibition provides a mechanism for regulating the size of
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